Argentine president looking at landslide victory (AP)

BUENOS AIRES, Argentina ? President Cristina Fernandez could rest easy ahead of Sunday's elections in Argentina, with polls suggesting a landslide victory over six rivals.

Not that she did: An irrepressible multitasker, she campaigned so hard that blood pressure problems repeatedly forced her to cancel events.

If she does win, she'll be the first woman president re-elected in Latin America. But it also will be a bittersweet victory for Fernandez, her first in a lifetime of politics without her husband and predecessor, Nestor Kirchner, who died of a heart attack last Oct. 27.

Since his death, Fernandez has reversed her negative numbers and proved her ability to govern on her own, ensuring loyalty or respect from an unruly political elite.

Many Argentines in pre-election polls said they would vote for her because their own financial situations have improved as the country's economy continues its longest spell of economic growth in history. Voters also said they supported Fernandez because she's best able to govern, which in Argentina often requires keeping union, corporate and social movement leaders in line.

Fernandez can win with as little as 40 percent of the vote if none of her rivals comes within 10 percentage points of her, but the latest polls suggested she could capture between 52 percent and 57 percent of votes. The surveys had error margins of plus or minus three percentage points.

If those trends hold, Fernandez could receive a larger share of votes than any president since Argentina's democracy was restored in 1983, when Raul Alfonsin was elected with 52 percent. She could even approach the 60 percent of ballots that her populist hero, Juan Domingo Peron, won in his last two elections. Her Front for Victory coalition also hoped to regain enough seats in Congress to form new alliances and regain the control it lost in 2009.

Fernandez, 58, chose her youthful, guitar-playing, long-haired economy minister, Amado Boudou, as her running mate. Together, the pair championed Argentina's approach to the global financial crisis: Increase government spending rather than impose austerity measures, and force investors in foreign debt to suffer before ordinary citizens.

Argentina has been closed off from most international lending since declaring its world-record debt default in 2001, but has been able to sustain booming growth ever since.

The country faces tough challenges in 2012, however. Its commodities exports are vulnerable to a global recession, and economic growth is forecast to slow sharply in the coming year. Declining revenues will make it harder to raise incomes to keep up with inflation. Trade with the economic powerhouse of Brazil is all important, but with the Brazilian real rising and the Argentine peso falling, there will be more pressure on Argentina's central bank to spend reserves to maintain the currency.

If his ticket wins, Boudou could win attention as a potential successor to Fernandez, but navigating these storms will require much skill and good fortune.

The president's rivals are Hermes Binner, 68, a doctor and socialist governor of Santa Fe province; Ricardo Alfonsin, 59, a lawyer and congressional deputy with the traditional Radical Civic Union party and son of the former president; Alberto Rodriguez Saa, 52, an attorney and governor of San Luis province whose brother Adolfo was president for a week; Eduardo Duhalde, who preceded Kirchner as president; leftist former lawmaker Jorge Altamira, 69; and Elisa Carrio 54, a congresswoman who came in second behind Fernandez four years ago but trailed the field this time.

Also at stake in the election are 130 seats in the lower house of congress, 24 senate seats and nine governor's offices as well as hundreds of local races.

Voting is obligatory in Argentina, and nearly 29 million citizens among the 40 million population are registered.

Source: http://us.rd.yahoo.com/dailynews/rss/latam/*http%3A//news.yahoo.com/s/ap/20111023/ap_on_re_la_am_ca/lt_argentina_election

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EU may combine insurance, SPIV to boost euro fund (Reuters)

BERLIN (Reuters) ? The euro zone should combine two proposals for increasing the firepower of its rescue fund -- an insurance model and a special purpose investment vehicle (SPIV) -- according to an EU paper for the mid-week summit obtained by Reuters on Monday.

The paper said neither option would require politically-difficult changes to the existing European Financial Stability Facility (EFSF), which has been approved by national parliaments after some problematic debates.

The euro zone wants to boost the firepower of its 440 billion euro bailout fund without putting more money into it.

With France dropping its idea of turning the fund into a bank to tap European Central Bank funds at a summit this weekend, EU leaders will decide at a second summit on Wednesday which of the two approaches left on the table should be used, with a combination looking increasingly likely.

Under the credit enhancement or insurance model, the EFSF could boost market confidence in new debt issued by a struggling member state by guaranteeing an unspecified proportion of the losses that could be incurred in the event of a default.

This would work via the EFSF extending a loan to a member state, which would buy EFSF bonds in return. The bonds would be the collateral for a partial protection certificate to be held in trust for the state. Both the bond and the certificate would be freely tradable, according to the paper.

If the state defaulted, the investor could surrender the protection certificate to the trust and receive payment from the EFSF. This option does not apply to states already receiving euro zone/International Monetary Fund bailouts as they are no longer issuing bonds on the primary market.

Under the SPIV scheme, one or more vehicles would be set up either centrally or in a beneficiary member state to invest in sovereign bonds in the primary and secondary markets.

Its structure -- the senior debt instrument could be credit rated and targeted at traditional fixed income investors -- is meant to attract international public and private investors, according to the paper.

"The SPIV ... would aim to create additional liquidity and market capacity to extend loans, for bank recapitalization via a member state and for buying bonds in the primary and secondary market with the intention of reducing member states' cost of issuance," the paper said.

The SPIV would be funded by freely traded instruments, such as senior debt and participation capital instruments. The EFSF would also invest in this, and would absorb the first proportion of losses incurred by the vehicle if a state defaulted.

The paper said the insurance option would not work for every member state because some are no longer on the primary market, and also because some have negative pledge clauses on existing debt, which prevent them from granting new security to creditors without granting existing creditors the same level of security.

It concluded that "the leverage which can be achieved can only be determined after dialogue with investors and rating agencies."

(Reporting by Matthias Sobolewski, writing by Annika Breidthardt)

Source: http://us.rd.yahoo.com/dailynews/rss/eurobiz/*http%3A//news.yahoo.com/s/nm/20111024/bs_nm/us_eurozone

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Reinventing Fire: Getting Beyond Fossil Fuels

In his bookReinventing Fire, Amory Lovins lays out his blueprint for freeing society of its addiction to fossil fuels, by saving energy with more efficient vehicles, buildings and manufacturing plants, and producing it with renewable options like windmills and rooftop solar.

Source: http://www.npr.org/2011/10/21/141591191/reinventing-fire-getting-beyond-fossil-fuels?ft=1&f=1007

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Japan's Tepco to sell 20 percent stake in wind power unit:Nikkei (Reuters)

TOKYO (Reuters) ? Tokyo Electric Power Co (9501.T) is likely to sell a 20 percent stake in wind power developer Eurus Energy Holdings to trading firm Toyota Tsusho (8015.T) to help raise funds to compensate victims of Japan's nuclear crisis, a newspaper said on Sunday.

Tokyo Electric, the owner of the crippled Fukushima Daiichi nuclear plant, is expected to sell the stake for a little less than 20 billion yen ($262 million) and post a profit of about 10 billion, which will be used for compensation, the Nikkei business daily reported.

The company, better known as Tepco, has issued a statement, saying that it has not made such a decision.

Tepco is still reeling from the radiation crisis at its Fukushima atomic plant triggered by the March 11 earthquake and tsunami in Japan's northeast.

It last month began accepting victims' applications for compensation, but the troubled utility needs to find funds to foot the cost and is seeking help from a taxpayer-funded bailout body.

Eurus Energy, currently owned 60 percent by Tepco and the rest by Toyota Tsusho, is Japan's biggest wind power developer and also operates wind power plants abroad.

Tepco is preparing an extraordinary operating plan, likely to include asset sales, cost cuts and other restructuring measures, and get government approval before receiving bailout funds.

(Reporting by Osamu Tsukimori; Editing by Yoko Nishikawa)

Source: http://us.rd.yahoo.com/dailynews/rss/science/*http%3A//news.yahoo.com/s/nm/20111023/bs_nm/us_tepco

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Scientists discover inflammation controlled differently in brain and other tissues

Scientists discover inflammation controlled differently in brain and other tissues

Friday, October 21, 2011

A team led by scientists from The Scripps Research Institute has identified a new metabolic pathway for controlling brain inflammation, suggesting strategies for treating it.

The new report, which appears in the October 20, 2011 edition of Science Express, focuses on the type of inflammation normally treatable with non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin or ibuprofen.

The study shows this type of inflammation is controlled by different enzymes in different parts of the body.

"Our findings open up the possibility of anti-inflammatory drugs that are more tissue-specific and don't have NSAIDs' side effects," said the study's senior author Benjamin F. Cravatt, chair of the Department of Chemical Physiology and member of the Skaggs Institute for Chemical Biology and the Dorris Neuroscience Center at Scripps Research.

A Serendipitous Discovery

The serendipitous discovery originated with an attempt by Cravatt and his colleagues to develop a new kind of pain-relieving drug targeting an enzyme known as monoacylglycerol lipase (MAGL). This enzyme normally breaks down a natural pain-relieving neurotransmitter known as 2-AG, a "cannabinoid" molecule whose actions are mimicked by certain compounds within marijuana. To reduce the rate of 2-AG breakdown, allowing 2-AG levels to rise and provide more pain relief, the Cravatt lab developed a powerful and selective MAGL-inhibiting compound, which the scientists described in 2009 and are still investigating as a possible pain drug.

In the course of this research, the scientists tested their MAGL inhibitor on mice and also engineered mice that genetically lack MAGL. "We noticed that the brains of the MAGL-inhibited mice showed reduced levels of arachidonic acid, a key precursor molecule for inflammatory lipids," said Daniel Nomura, a former member of the Cravatt lab who is currently assistant professor in the Department of Nutritional Science & Toxicology at the University of California, Berkeley. Nomura is the paper's co-corresponding author with Cravatt, and co-first author with Bradley E. Morrison of Scripps Research.

Arachidonic acid had been thought to originate similarly throughout the body, from a process involving fat molecules and phospholipase A2 enzymes. To their surprise, the researchers found that in the brain, arachidonic acid production is controlled chiefly by MAGL.

In effect, the enzyme takes pleasure-associated 2-AG, which is found in high concentrations in the brain, and turns it into arachidonic acid?the precursor for pain- and inflammation-causing prostaglandin molecules. The researchers showed that blocking the activity of MAGL, or genetically eliminating it, shrinks the pool of arachidonic acid and prostaglandins in mouse brains, effectively limiting the possibility of brain inflammation.

Providing a Protective Effect

To further test this effect, the researchers set up two standard models of brain inflammation in lab mice. In one, they tried to induce inflammation with lipopolysaccharide, a highly pro-inflammatory molecule found in bacteria. In the other, they used the toxin MPTP, which induces brain inflammation and preferentially kills the same muscle-regulating neurons lost in Parkinson's disease.

"In both models, reducing MAGL ? genetically or with our MAGL-inhibitor ?provided the animals with protection from neuroinflammation," said Nomura, who is continuing to research the system at UC Berkeley.

NSAIDs such as ibuprofen are already used to reduce the inflammation that originates from arachidonic acid. They work by inhibiting the cyclo-oxygenase enzymes that convert arachidonic acid into prostaglandins. But NSAIDs also inhibit cyclo-oxygenase enzymes that protect the lining of the gastrointestinal tract. They thus can cause gastrointestinal bleeding, among other adverse side effects. That greatly limits their potential usefulness. In the brain, where MAGL is the major controller of arachidonic acid levels, blocking the enzyme could be a better strategy. Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury all involve harmful but potentially treatable brain inflammation.

"In principle, with a MAGL inhibitor we could avoid the gastrointestinal toxicity that's associated with NSAIDs while still maintaining the anti-inflammatory effect," said Nomura.

Unexpected Elements

The new findings also are important from a basic science perspective because they advance the understanding of prostaglandin-mediated inflammation. Phospholipase A2 enzymes have long been considered the dominant producers of arachidonic acid, and thus a major element in prostaglandin-mediated inflammation throughout the body.

Nomura, Cravatt, and their colleagues confirmed in their experiments that phospholipase A2 enzymes play a major role in arachidonic acid production in the gut and spleen. However, in the brain, the MAGL enzyme was the principal regulator, with phospholipase A2 enzymes making a more limited contribution. MAGL also regulated arachidonic acid and prostaglandins in liver and lungs.

"Biological pathways that we think we understand sometimes turn out to have these unexpected, tissue- or context-specific elements, which is why it's so important to follow up on clues such as the ones we found," Cravatt said.

###

Scripps Research Institute: http://www.scripps.edu

Thanks to Scripps Research Institute for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/114513/Scientists_discover_inflammation_controlled_differently_in_brain_and_other_tissues

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Defunct German Satellite Hits Earth in Fiery Death Dive (SPACE.com)

An old German satellite fell to Earth today (Oct. 22), after languishing in a dead orbit since it was decommissioned more than a decade ago, but officials do not yet know where it fell.

The 2.7-ton Roentgen Satellite, or ROSAT, slammed into Earth's atmosphere sometime between 9:45 p.m. EDT (0145 GMT Sunday) and 10:15 p.m. EDT (0215 GMT Sunday), according to officials at the German Aerospace Center.

"There is currently no confirmation if pieces of debris have reached Earth's surface," German aerospace officials said in a statement.

While the 21-year-old satellite broke apart as it re-entered Earth's atmosphere, German aerospace officials estimated that up to 30 pieces totaling 1.9 tons (1.7 metric tons), consisting mostly of the observatory's heat-resistant mirrors and ceramic parts, could survive the fiery trip and reach the surface of the planet.

Based on ROSAT's orbital path, these fragments could be scattered along a swath of the planet about 50 miles (80 kilometers) wide, German aerospace officials have said.

The satellite, which weighs 5,348 pounds (2,426 kilograms), was launched into orbit in June 1990 to study X-ray radiation from stars, comets, supernovas, nebulas and black holes, among other things. The satellite was originally designed for an 18-month mission, but it far outlived its projected lifespan. [Photos of Doomed ROSAT Satellite]

In 1998, the ROSAT's star tracker failed and its X-ray sensors pointed directly at the sun. This caused irreparable damage to the satellite, and it was officially decommissioned in February 1999.

The defunct German X-ray observatory was the second satellite to fall uncontrolled from space within a roughly 30-day period. On Sept. 24, a 6.5-ton, decommissioned NASA climate satellite, called the Upper Atmosphere Research Satellite (UARS), plummeted into the Pacific Ocean. The event sparked a media frenzy around the world, and some pranksters even seized the opportunity to create hoax videos and images of the satellite's fall.

Mission controllers initially estimated that ROSAT could fall to Earth in November, but increased solar activity caused the satellite's orbit to decay faster than originally expected. As the sun's activity ramps up, it heats up and expands the atmosphere, which creates more drag on satellites in orbit.

ROSAT's fall from space, and the UARS satellite before it, shone a spotlight on the growing problem of debris in space.

"One option is we want to be able to catch uncontrolled satellites in the future," Jan Woerner, head of the executive board of the Deutsches Zentrum f?r Luft- und Raumfahrt (DLR), Germany's space agency, told SPACE.com. "We're working on such a mission to catch them, depending on their state, and have a controlled re-entry or send them to a graveyard, in order to prevent this situation in the future."

NASA's bus-size UARS satellite was the largest satellite to fall uncontrolled from orbit since 1979. Skylab, the first American space station, plummeted to Earth in 1979, and debris from the complex plunged into the Indian Ocean and onto parts of Australia.

Also in 1979, NASA's Pegasus 2 satellite, which was launched in 1965 to study micrometeoroids in low-Earth orbit, re-entered the atmosphere uncontrolled and splashed into the mid-Atlantic Ocean.

You can follow SPACE.com staff writer Denise Chow on Twitter @denisechow. Follow SPACE.com for the latest in space science and exploration news on Twitter @Spacedotcom and on Facebook.

Source: http://us.rd.yahoo.com/dailynews/rss/science/*http%3A//news.yahoo.com/s/space/20111022/sc_space/defunctgermansatellitehitsearthinfierydeathdive

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Microsoft has record Q1, rakes in $17.37 billion in revenue (updated: Skype plans revealed)

Microsoft Q1 2012 earnings
Q1 of 2012 (don't ask...) was good to Microsoft. Very good in fact. The company posted a record first quarter revenue of $17.37 billion, a 7-percent increase over the same period last year and slightly higher than the $17.26 billion that was expected. The big hero was Office which accounted for $5.62 billion of that income, though sales of Windows stayed flat and fell somewhat short of expectations. The company's $5.74 billion in net income was also a significant jump of 6-percent over the same time last year. For a few more of the financial particulars check out the earnings report after the break and the spartan spreadsheets at the source link.

Update: Wondering what Microsoft plans to do with the newly acquired Skype? Well, details are thin, but during today's earnings call the company revealed it did plan to integrate the VoIP service and its technologies into Lync, Live Messenger and Xbox Live. Soon you may not only have to listen to your friend gloat after every kill in Call of Duty, you might have to watch him do a celebratory dance in his Lazy Boy too.

Continue reading Microsoft has record Q1, rakes in $17.37 billion in revenue (updated: Skype plans revealed)

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Source: http://www.engadget.com/2011/10/20/microsoft-has-record-q1-rakes-in-17-37-billion-in-revenue/

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The Iraq War, by the Numbers (ContributorNetwork)

On Friday, President Barack Obama announced the end of the Iraq War, saying that U.S. troops will be leaving the country by the end of the year. This comes after many talks with the Iraqi Prime Minister Nouri al-Maliki, who at first had expressed concerns that the Iraqi forces would need a U.S. presence to remain in his country as a training force. The Iraq War, or Operation Iraqi Freedom has been a very long and arduous road for all involved. Here is some more information on this war by the numbers.

* 4,287: The number of U.S. troops who were killed in Iraq.

* 30,182: The number of U.S. troops who were wounded in Iraq.

* 112,708: The estimated number of civilians killed in Iraq during Operation Iraqi Freedom.

* 318: The number of non-U.S. troop deaths in Iraq.

* 468: The number of contractors killed in Iraq.

* 150: The number of journalists killed in Iraq.

* 2003: The year in which the deadliest month for civilian deaths in Iraq took place in March with 3,977 being killed.

* 63 percent: The percentage of soldiers who have deployed to Iraq at least once.

* 40 percent: The percentage of soldiers who have deployed to Iraq at least twice.

* 90 percent: The percentage of United States Marines who have deployed to Iraq.

* 15 months: The average length of deployment for soldiers before August 2008 in Iraq.

* 500 per month: The number of calls that the Domestic Violence Hotline for military spouses has received since the start of the Iraq war. The average used to be 50 calls per month.

* 40,000: The approximate number of troops still serving in Iraq.

* $799,981,238,000: The approximate cost to date of the Iraq War.

* $270 million: The amount of daily spending by the U.S. government in Iraq.

* $9 billion: The amount of unaccounted for U.S. taxpayer money that was supposed to be used for the Iraq War.

* 190,000: Number of guns that were either lost or unaccounted for during Operation Iraqi Freedom.

* 12 percent to 20 percent: The estimated percentage of troops who have served in Iraq coming home with Post Traumatic Stress Disorder or PTSD.

* 300,000: The estimated number of mental health casualties from the Iraq War, meaning the number of veterans who are experiencing severe mental problems due to their service in Iraq.

* $660 billion: The amount of money that it is going to take to treat these Iraq War veterans for their lifetimes.

* 1.6 million: The number of Iraqi civilians who have been displaced because of the ongoing war.

Lauren Finnegan graduated from Hawaii Pacific University with a bachelor's degree in political science and has an insider's perspective on the military because of her role as a military wife who has lived around the country.

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/ac/20111021/us_ac/10259253_the_iraq_war_by_the_numbers

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Blue Arkansas ? Blog Archive ? How To Get The Finest Automotive ...

October 22nd, 2011
By RenitaEvelynn816

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There are particular elements that might have an effect on the price of your automotive insurance, for example the number of years no claims bonus you might have, the size and worth of your automotive, the common mileage a yr that you drive and the additional security features your automobile has been put in with. Somebody who drives a smaller automobile, with a smaller engine and who has a low common annual mileage will get a greater automobile insurance deal than somebody who has acquired an enormous car and has acquired a high annual mileage.

In case you have an automobile that is outfitted with enhanced security measures really helpful by insurance coverage sellers like an automobile alarm, tracker or immobiliser you?ll get cheaper automobile insurance coverage simply because your automobile shall be safer and less likely to stolen when parked and left unattended, in the same means by parking your automobile overnight in a garage or on a driveway this may even assist to scale back the cost of your automotive insurance.

Yearly when the renewal for your automotive insurance is due do not simply renew your automobile insurance coverage earlier than you talk to an automobile insurance coverage broker. They are going to make sure that you get the perfect automotive insurance coverage deal once more this year. Never take it with no consideration that the insurance deal you bought last 12 months will nonetheless be the most cost effective this year.

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Source: http://bluearkansasblog.com/?p=7890

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Palestinians: Israel offered halt in settlements (AP)

JERUSALEM ? A Palestinian negotiator claimed Friday that Israel offered to halt a limited amount of construction work in Jewish settlements in the West Bank in an effort to find a way to restart peace negotiations.

The offer suggests Israeli officials are quietly trying to find ways of restarting negotiations that would ultimately lead to the creation of a Palestinian state.

Saeb Erekat said the offer came last month through a foreign envoy who conveyed a message from Israeli Prime Minister Benjamin Netanyahu.

An Israeli official denied the offer was made. He spoke on condition of anonymity because of the sensitivity of the issue.

Erekat said the Palestinians dismissed it because it applied only to government construction. Most settlement building is done by private contractors, said Hagit Ofran of Peace Now, an anti-settlement Israeli watchdog.

"If Netanyahu wants to resume negotiations, he has to say that settlement building will stop. Either it stops or it doesn't stop," Erekat said.

Palestinians say they will not negotiate with Israel while settlement building continues in the West Bank and east Jerusalem. Israel has said the issue must be on the negotiating table and not serve as a precondition.

Israel captured the territories in the 1967 Mideast war, and has annexed east Jerusalem ? a move that the international community doesn't recognize.

Some half million Israeli Jews live in the West Bank and east Jerusalem. Palestinians say their presence, particularly in areas around Jerusalem and deep in the West Bank, would make the emergence of a viable state impossible.

Israeli-Palestinian negotiations sputtered to a halt long ago over the issue of settlement construction.

Israel agreed in the past to slow down settlement building for 10 months, but Palestinians only agreed to negotiate in the last few weeks of that period. Israeli officials refused to renew the slowdown, despite heavy U.S. pressure to do so.

Also in the West Bank Friday, Palestinians said they were attacked by Jews while trying to reach their olive orchards.

Such attacks often take place during the fall olive harvest season.

Farmer Fuad Hamoud and volunteer Sari Harb said they were walking toward farmlands in the West Bank village of Jaloud when a group of masked Jewish men hurled rocks and beat some of them with sticks.

One man and a 15-year-old youth were taken to a hospital with head wounds, Palestinians said.

The village lies close to several hard-line Jewish settlements.

An Israeli army spokeswoman said it wasn't clear how the clash began. Jewish settlers were not immediately available for comment.

Source: http://us.rd.yahoo.com/dailynews/rss/mideast/*http%3A//news.yahoo.com/s/ap/20111021/ap_on_re_mi_ea/ml_israel_palestinians

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