First non-game titles now available on Steam, game dev tools lead the charge

First nongame titles now available on Steam,

Valve Software -- maker of the iconic Half-Life series and proprietor of digital storefront Steam -- today released Steam's first non-video game software (originally scheduled to launch in early September). ArtRage Studio Pro, CameraBag 2, GameMaker: Studio, 3D-Coat, 3DMark Vantage, and 3DMark 11 join Valve's own Source Filmmaker in the newly minted software section of the Steam store. All non-Valve software is PC-only for now -- we imagine Mac software will also show up at some point, but nothing's available just yet. Like Steam's games, software titles will receive streamlined updates via the Steam client, and consumers will enjoy similar discount offers to the games section -- the first such sale is already on, with launch day software getting a 10 percent discount until week's end. Bizarrely, the software titles also have Steam achievements. Finally, developers get rewarded for porting their games to Android by something other than crushing piracy!

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First non-game titles now available on Steam, game dev tools lead the charge originally appeared on Engadget on Tue, 02 Oct 2012 15:31:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/10/02/steam-non-game-software-launch/

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How a Secret Sequence of Doorbell Buzzes Can Unlock Your Home With [Video]

If you're tired of digging out your house keys when you get home, take a look at this brilliant workaround by Piet De Vaere. He hacked his doorbell to listen for a secret sequence of button presses that automatically unlocked the gate in front of his house. As long as you've got a great memory, you can shed a few of the keys in your pocket. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Cr-bFFz7xGk/how-a-secret-sequence-of-doorbell-buzzes-can-unlock-your-home-with

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Thousands of Millionaires Collect Unemployment

A new report shows that some 2,400 millionaires received unemployment insurance benefits during the economic downturn, a number that has caught the attention of politicians who funded extensions of benefits for up to 99 weeks as the economy crumbled.

In 2009, 2,362 millionaires received unemployment benefits, down from 2,840 the year prior, according to a study from the Congressional Research Service, a non-partisan arm of U.S. Congress that provides policy and legal analysis. Of the 2,362 more than 1,000 receiving unemployment benefits had a household adjusted gross income of $1.5 million in 2009.

The report titled "Receipt of Unemployment Insurance by Higher-Income Unemployed Workers" found that 0.02 percent of tax filers that received unemployment benefits in 2009 were millionaires. A total of $20.8 million in unemployment benefits went to this group.

"It sounds scandalous when you hear that millionaires are going to collect unemployment insurance," Bill Frenzel, guest scholar at the Brookings Institute and former Republican member of Congress, told ABC News. "On the other hand, millionaires get unemployed too and have made payments into the unemployment insurance."

In 2010, 4.6 million people were kept out of poverty due to unemployment benefits, according to the Center on the Budget and Policy Priorities.

Frenzel says if they made a million dollars in income the year prior, "they could probably stand being barred from unemployment this year."

And, apparently one member of Congress agrees.

"Sending millionaires unemployment checks is a case study in out-of-control spending. Providing welfare to the wealthy undermines the program for those who need it most while burdening future generations with senseless debt," Republican Senator Tom Coburn, M.D. of Oklahoma said in a statement to ABC News. Based on the report from the Senator's office, millionaires received $74 million in unemployment insurance from 2005 to 2009.

According to the Center on Budget and Policy Priorities, the average individual collects about $300 per week from unemployment compensation.

Early last year, Sen. Coburn introduced " Ending Unemployment to Jobless Millionaires Act of 2011," which is currently languishing in the House of Representatives, a bill which sought to halt payment of federal funds for unemployment compensation to individuals whose "resources in the preceding year" was $1 million or more.

But millionaires aren't the only individuals to benefit from unemployment benefits. A few other high-income brackets receive compensation from the government. More than 8,000 tax filers making $500,000 to $1,000,000 received unemployment benefit income in 2009 and more than 900,000 tax filers that made $100,000 to $500,000 received unemployment benefit income.

Also Read

Source: http://news.yahoo.com/thousands-millionaires-collect-unemployment-202755783--abc-news-savings-and-investment.html

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Fix iPhone Apps Stuck "Waiting" During Installation [IPhone]

Fix iPhone Apps Stuck "Waiting" During InstallationEver have one of those apps you're trying to install on your iPhone or iPad that just refuses to get past the "Waiting" screen and start the installation process? It's annoying, but tech blog Digital Inspiration shares a few of the trick to fix the process.

When you open up the iTunes App Store and try to install an app, occasionally the process hangs a the "Waiting" screen, and you're stuck sitting there waiting for it to do something. To fix this, you'll need to do one of four things:

  1. You can download the app on your computer using iTunes and then sync to transfer the app to your iPhone /iPad.
  2. Or, long-tap the icon on the home-screen until the icons begins to shake. Now delete the "waiting" app and reinstall it from the iTunes store. This isn't the best option as you may lose some of the custom settings that were previously associated with the app.
  3. Or, single tap the app's icon on the home screen and it will pause the download. Now go back to the iTunes Apps store, switch to the "Updates" screen and click "Update" to resume the download. This is what I do on my iOS device and the fix works most of the times.
  4. Or, go to Settings -> iTunes & App Stores and tap the Apple ID to sign-out. Restart the iPad, go back to Settings -> iTunes Apps Store and sign-in. Tap the waiting icon to update the app.

I've had the best luck on iOS 6 with the third method listed here, especially when I'm upgrading five or six apps at once. Your mileage may vary though, so try any of the above.

How to Download iOS Apps Stuck on "Waiting.." | Digital Inspiration

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/YCC_xXxpzjg/fix-iphone-apps-stuck-waiting-during-installation

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Undersea 6.2 magnitude quake strikes off northeast Japan

NEW YORK (Reuters Health) - Both doctors and patients gave high marks to a program allowing patients to access their primary care physicians' office notes online, in a new study. Researchers at three U.S. practices found doctors' initial concerns about the extra time it would take to write out notes and answer patients' related questions didn't pan out. And almost everyone who got access to their notes for the study wanted to keep seeing them, even if some patients were concerned about privacy issues. "We were thrilled by what we learned," said Dr. ...

Source: http://news.yahoo.com/undersea-6-2-magnitude-quake-strikes-off-northeast-225502617.html

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Breast Cancer Awareness Month is a longtime commitment for Elizabeth Hurley

NEW YORK, N.Y. - After nearly two decades, Elizabeth Hurley still finds herself dressed in pink in October to mark Breast Cancer Awareness Month.

She's been the face of the Estee Lauder Cos.' breast-cancer awareness and fundraising efforts for 18 years.

"This is a part of my life. I look forward to the month. Over the years, my commitment has become more significant," Hurley says.

The calendar is marked off for the entire month, the actress says, and she makes no other plans, although she's hoping to squeeze in a diner breakfast on this trip to New York City.

Hurley, 47, was at the Empire State Building on Monday wearing a plunge V-neck, gathered-waist Issa jersey dress to flip the switch to turn the lights pink. She did it two years ago with Evelyn Lauder, who died last November.

Lauder co-founded the Pink Ribbon Campaign 20 years ago, and since then, more than 122 million free pink ribbons have been handed out at department-store cosmetic counters as a reminder about breast health and the research being done for a cure, Hurley says.

"We were a great double act. This is bittersweet. ... She was a wonderful person, and I hope a little bit rubbed off on me."

Without Lauder, Hurley finds herself busier this month, with planned stops in Toronto, London and Paris, among others. The campaign reaches 70 countries.

"If you open up my suitcase, you'll see a lot of pink dresses, nude-colored shoes and a lot of pink handbags, too," she says.

The campaign has found much success raising money for research: $35 million so far, Hurley says, though, it's with each mammogram made by a woman who might otherwise have forgotten or resisted to make that call for her appointment that she feels a greater sense of accomplishment.

William Lauder, Evelyn's son and executive chairman of the cosmetics company, says he gets a little thrill ? and a giant burst of pride ? every time an NFL football player puts on a pair of hot pink gloves or uses a pink towel to support the breast cancer campaign.

He remembers his mother establishing the Breast Cancer Research Foundation in 1993 and making it her life's work.

It now seems hard to imagine an October not washed in pink, Hurley and William Lauder agree.

There's also a perk in all the pink lip gloss that goes along with the campaign, adds Hurley. There's one this year named for her called Pink Innocence.

"I love it when I get the new gloss, and when I see other people wearing it."

An interactive exhibition looking back at the 20 years of the Breast Cancer Awareness campaign is open to the public Tuesday and Wednesday outside the GM Building on Fifth Avenue.

Source: http://news.yahoo.com/breast-cancer-awareness-month-longtime-commitment-elizabeth-hurley-200716375.html

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Immune system harnessed to improve stem cell transplant outcomes

ScienceDaily (Oct. 1, 2012) ? A novel therapy in the early stages of development at Virginia Commonwealth University Massey Cancer Center shows promise in providing lasting protection against the progression of multiple myeloma following a stem cell transplant by making the cancer cells easier targets for the immune system.

Outlined in the British Journal of Hematology, the Phase II clinical trial was led by Amir Toor, M.D., hematologist-oncologist in the Bone Marrow Transplant Program and research member of the Developmental Therapeutics program at VCU Massey Cancer Center. The multi-phased therapy first treats patients with a combination of the drugs azacitidine and lenalidomide. Azacitidine forces the cancer cells to express proteins called cancer testis antigens (CTA) that immune system cells called T-cell lymphocytes recognize as foreign. The lenalidomide then boosts the production of T-cell lymphocytes. Using a process called autologous lymphocyte infusion (ALI), the T-cell lymphocytes are then extracted from the patient and given back to them after they undergo a stem cell transplant to restore the stem cells' normal function. Now able to recognize the cancer cells as foreign, the T-cell lymphocytes can potentially protect against a recurrence of multiple myeloma following the stem cell transplant.

"Every cell in the body expresses proteins on their surface that immune system cells scan like a barcode in order to determine whether the cells are normal or if they are foreign. Because multiple myeloma cells are spawned from bone marrow, immune system cells cannot distinguish them from normal healthy cells," says Toor. "Azacitidine essentially changes the barcode on the multiple myeloma cells, causing the immune system cells to attack them," says Toor.

The goal of the trial was to determine whether it was safe, and even possible, to administer the two drugs in combination with an ALI. In total, 14 patients successfully completed the investigational drug therapy. Thirteen of the participants successfully completed the investigational therapy and underwent a stem cell transplant. Four patients had a complete response, meaning no trace of multiple myeloma was detected, and five patients had a very good partial response in which the level of abnormal proteins in their blood decreased by 90 percent.

In order to determine whether the azacitidine caused an increased expression of CTA in the multiple myeloma cells, Toor collaborated with Masoud Manjili, D.V.M., Ph.D., assistant professor of microbiology and immunology at VCU Massey, to conduct laboratory analyses on bone marrow biopsies taken from trial participants before and after treatments. Each patient tested showed an over-expression of multiple CTA, indicating the treatment was successful at forcing the cancer cells to produce these "targets" for the immune system.

"We designed this therapy in a way that could be replicated, fairly inexpensively, at any facility equipped to perform a stem cell transplant," says Toor. "We plan to continue to explore the possibilities of immunotherapies in multiple myeloma patients in search for more effective therapies for this very hard-to-treat disease."

In addition to Manjili, Toor collaborated with John McCarty, M.D., director of the Bone Marrow Transplant Program at VCU Massey, and Harold Chung, M.D., William Clark, M.D., Catherine Roberts, Ph.D., and Allison Hazlett, also all from Massey's Bone Marrow Transplant Program; Kyle Payne, Maciej Kmieciak, Ph.D., from Massey and the Department of Microbiology and Immunology at VCU School of Medicine; Roy Sabo, Ph.D., from VCU Department of Biostatistics and the Developmental Therapeutics program at Massey; and David Williams, M.D., Ph.D., from the Department of Pathology at VCU School of Medicine, co-director of the Tissue and Data Acquisition and Analysis Core and research member of the Developmental Therapeutics program at Massey.

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The above story is reprinted from materials provided by Virginia Commonwealth University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Amir A. Toor, Kyle K. Payne, Harold M. Chung, Roy T. Sabo, Allison F. Hazlett, Maciej Kmieciak, Kimberly Sanford, David C. Williams, William B. Clark, Catherine H. Roberts, John M. McCarty, Masoud H. Manjili. Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity. British Journal of Haematology, 2012; 158 (6): 700 DOI: 10.1111/j.1365-2141.2012.09225.x

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/wTH9xIbbOM0/121001161444.htm

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